Pharmacology Effectiveness of streptokinase in Acute Miocardial Research Paper

Pharmacology Effectiveness of streptokinase in Acute Miocardial Infarction - Research Paper Example The administration of aspirin and heparin before the treatment will increase the survival rate. Introduction: Acute myocardial infraction is the breakdown of the heart muscles due to the lack of oxygen supply. The shortage in oxygen supply is caused by the collection of lipids at the heart muscles. This creates a block in the blood vessels resulting in ischemia and if left untreated it results in infraction of the myocardial cells. The risk factors of acute myocardial infarction (AMI) are cardiovascular disease, tobacco smoking, older age, kidney diseases, blood pressure, excessive alcohol consumption and obesity. Streptokinase is one of the first thrombolytic agent to be used for the treatment of Acute myocardial infarction. Streptokinase was discovered in the year 1933 by Dr. William Smith Tillett. The use of Streptokinase for the treatment of acute myocardial infarction started in the year 1947 when Sol Sherry identified the potential of streptokinase. (Sikri and Bardia, 2007).The clinical trials using streptokinase started thereafter. They concluded that streptokinase can be used to treat hemothorax, purulent and sanguineous pleural exudations, fibrinous and tuberculosis meningitis. (Sikri and Bardia, 2007).The difficulties in purifying the protein streptokinase led to the delay in the intravenous use. The intravenous use of streptokinase was started in the year 1952. This proved to be a promising approach. ... Streptokinase binds to the circulating plasminogen and forms a complex. This complex activates the plasminogen through a three step mechanism. If fibrin is present, then the streptokinase – plasmin complex forming capacity gets increased and thus lyses the clots. (Becker, 1997). After infusion of the clot, the streptokinase spreads through the plasma. There are two phases of streptokinase clearance. The half life of first phase streptokinase is 11-17 minutes and that of the second phase is 85 minutes. The current recommended dose level of streptokinase is 1.5 million units for 30- 60 minutes. (Becker, 1997). The main drawback of streptokinase is that it is antigenic. The administration of streptokinase produces antibodies in the blood. The antibodies formed may neutralize the drug. (Becker, 1997). Development: After the discovery of Streptokinase in the year 1933, the mechanisms of action of streptokinase in humans were determined. In 1959, Ruegsegger discovered the intracoron ary clots. Many clinical trials were conducted at this time. There was a small risk of allergy. Many investigators considered this to be the plausible option for the treatment of acute myocardial infraction. In the year 1985 many small trials were conducted to standardize the protocol for streptokinase but no trial produced positive result. Finally they concluded that when the drug was administered for 1.5 to 3 hours, they were able to receive reperfusion rate of 90%. (Sikri and Bardia, 2007). GISSI Trial: Gruppo Italiano per la Sperimentazione della Streptochinasi nell'Infarto Miocardico ( GISSI) trial was conducted as the large scale trial. 11806 patients were enrolled in the study for a period of 17 months in 176 coronary heart care centre. New patients were recruited at a rate of

Exam econmic of race and gender Essay Example | Topics and Well Written Essays - 500 words

Exam econmic of race and gender - Essay Example rmulated as a response to the decisions of the United States Supreme Court which had led to the rights of the employees being limited since they sued their employers for discrimination. a) The term paper was on the topic, â€Å"Instances of gender discriminatory behaviors at work places†. This helped me identify with the discrimination that people face at work and also allowed for a clearer understanding of the various acts and laws in place to resolve these issues. On the whole, the term paper was very beneficial in better understanding of the subject as a whole. Working on the gender discriminatory behavior at work has not only helped in this class but is also a beneficial learning for how work environments actually function. Here this report has been detailed with complete insight into affirmative action and how it works. This provides a practical experience and helps relate better to subject. There is also clarity of various cases and the outcomes of the cases which make it simpler to understand the subject rather than simply learning the laws directly. b) The group presentation was on the topic â€Å"Affirmative Action losing favor in the United States†. This presentation has been very helpful for the course as it helps bring out the views and opinions of the students on affirmative action. The presentation was divided into three main parts, i.e. history of affirmative action, diversity rationale and the main discussion of whether affirmative action is losing favor. The presentation was in its own way a chance for us to study the literature carefully and in detail. The presentation helped each of us work on different part individually which helped in understanding the subject to a greater extent. On the whole this presentation not only helped us learn the topic more in detail but also lead us to use our knowledge to correlate to the success of the affirmative action. This I believe brought about a lot of discussions and views which were not otherwise